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A new study co-led by professor Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology, published in Nature Genetics, uncovers how the three-dimensional organization of DNA in rare immune cells can help explain genetic risk for Crohn's disease and oth

Acute myeloid leukemia (AML) is an aggressive blood cancer that remains difficult to treat. While targeted therapies have improved outcomes for some patients, many relapse when a small population of cancer stem cells survives treatment and seeds the disease again.

All living organisms need vitamin B12 to form red blood cells and DNA, as well as to build and support brain and nerve cells. But it's hard to come by: Humans don't make it. Animals don't make it. Plants don't make it. In fact, this essential nutrient is made exclusively by certa

One of the many ways obesity harms the human body is through damage to skeletal muscle. This progressive muscle decline, also known as sarcopenia, reduces strength, mobility and the ability to live independently. Unfortunately, most therapies for obesity and related conditions li

Understanding how heart muscle cells stop dividing and acquire the characteristics needed to sustain lifelong cardiac function remains one of the greatest challenges in cardiovascular biology. Leveraging human induced pluripotent stem (iPS) cell technology, a team led by Associat

Most cancer deaths are caused not by the initial tumor but by the spread of cancer cells to distant organs in the process called metastasis. Since it occurs at the cellular level, the earliest stages of metastasis are difficult to observe in patients. A new study, published in Sc

New research from an expert in cancer biology explains what triggers liposarcoma cells to become more or less aggressive and identifies potential targets that could keep aggressive tumors in check. A study led by Blake Wilde, Ph.D., of Roswell Park Comprehensive Cancer Center hig

Low arginine levels may allow cancer cells and viruses to slip past the immune system by reducing production of a crucial cellular warning protein. In mice, arginine-rich diets led to fewer colon tumors and milder viral infections, suggesting a simple supplement could have powerf

Stanford researchers discovered immune cells in flatworms that explode within minutes, killing nearby bacteria and foreign cells before vanishing completely. Their unusually fast and localized attack could offer clues for developing targeted treatments against infections and canc

Using simple artificial cells, a research group led by Makito Miyazaki of the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has uncovered fundamental physical principles that govern how living cells change their shape. By combining experiments with computer simulat

Researchers at Karolinska Institutet and SciLifeLab have developed a new method to analyze the condition of immune cells in the blood. The method has been tested on patients with atherosclerosis and can distinguish their immune cells from those of healthy individuals. The study i

New research reveals that cells of the same chronological age can follow dramatically different biological aging paths, offering new insights into cancer, neurodegeneration and the fundamental biology of aging. Rather than aging uniformly, tissues become a mosaic of biologically